Inhibition of Ribonucleotide Reductase Activity by IC202C
نویسندگان
چکیده
منابع مشابه
Inhibition of ribonucleotide reductase activity by IC202C.
suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
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In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus solfataricus with HU, we observe dose-dependent cell cycle arrest, accumulation of DNA double-strand...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2001
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.54.682